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Scientists develop safer and more sustainable antimicrobials to prevent infection of cow udders

The dairy industry has been plagued by a persistent global problem for decades—bacterial infection of cow udders that significantly reduces milk production.

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Proteome analysis can predict biological effects of yeast mutations

Every organism's genome contains mutations that often have unknown biological effects. In partnership with Stanford University, researchers at Charité—Universitätsmedizin Berlin have now discovered a way to predict the effects of numerous mutations in yeast.

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Peptide nanotubes show promise for overcoming chemotherapy resistance

A research team at CiQUS (University of Santiago de Compostela, Spain) has unveiled an innovative molecular approach that enables anticancer drugs to reach the nucleus of tumor cells, where they can exert their therapeutic effect. The study focused on doxorubicin, a widely used chemotherapy agent. Prolonged exposure to this drug often leads to the emergence of resistant cells, a major clinical challenge that this strategy successfully overcomes while preserving the drug's antitumor activity.

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New tool offers single-cell study of specific genetic variants

Scientists have long suspected connections between heredity and disease, dating back to Hippocrates, who observed certain diseases "ran in families." However, through the years, scientists have kept getting better at finding ways to also understand the source of those genetic links in the human genome.

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Destined to melt: Study warns glaciers' ability to cool surrounding air faces imminent decline

Glaciers are fighting back against climate change by cooling the air that touches their surfaces. But for how long? The Pellicciotti group at the Institute of Science and Technology Austria (ISTA) has compiled and re-analyzed an unprecedented dataset of on-glacier observations worldwide. Their findings, published today in Nature Climate Change, demonstrate that glaciers will likely reach the peak of their self-cooling power by the next decade before their near-surface temperatures spike up and melting accelerates.

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Molecular switch discovery could open door to male birth control

Michigan State University scientists have pinpointed the molecular "switch" that supercharges sperm for their final sprint to an egg—a breakthrough that could reshape infertility treatments and pave the way for safe, nonhormonal male contraceptives. The work is published in the journal Proceedings of the National Academy of Sciences.

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To prevent rapid sea-level rise, study urges reducing emissions now

The timing of emissions reductions, even more so than the rate of reduction, will be key to avoiding catastrophic thresholds for ice-melt and sea-level rise, according to a new Cornell University study.

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Holocene skeletal samples challenge link between sedentary lifestyles and age-related bone weakening

Research led by Vladimír Sládek sheds new light on how bones age, questioning long-standing assumptions that sedentary lifestyles are the primary cause of weakening bone strength in modern humans.

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Microwave technique allows energy-efficient chemical reactions

Some industrial processes used to create useful chemicals require heat, but heating methods are often inefficient, partly because they heat a greater volume of space than they really need to. Researchers, including those from the University of Tokyo, devised a way to limit heating to the specific areas required in such situations. Their technique uses microwaves, not unlike those used in home microwave ovens, to excite specific elements dispersed in the materials to be heated. Their system proved to be around 4.5 times more efficient than current methods.

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Unified model explains extreme jet streams on all giant planets

One of the most notable properties of the giant planets in our solar system—Jupiter, Saturn, Uranus and Neptune—are the extreme winds observed around their equators. While some of these planets have eastward equatorial winds, others have a westward jet stream. For the first time, an international team of scientists led by Leiden Observatory and SRON, can explain the winds on all the giant planets using one model.

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A new scalable approach to realize a quantum communication network based on ytterbium-171 atoms

Quantum networks, systems consisting of connected quantum computers, quantum sensors or other quantum devices, hold the potential of enabling faster and safer communications. The establishment of these networks relies on a quantum phenomenon known as entanglement, which entails a link between particles or systems, with the quantum state of one influencing the other even when they are far apart.

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Saturday Citations: AI chatbots are insincere; childhood memory recall; a tiny chunk of dark matter

This week, researchers discovered so-called "switchbacks" in Earth's magnetic field similar to observations of switchbacks in the sun's magnetic field. Scientists provided more evidence that ancient Rapa Nui engineers "walked" Easter Island's iconic statues along carefully designed roads. And satellite imagery revealed a record 20-meter-high ocean wave. We also reported on a unique method for eliciting childhood memories, the smallest chunk of dark matter ever observed, and the pernicious effects of empty praise from chatbots:

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Fundamental engineering principles can help identify disease biomarkers more quickly

People often compare the genome to a computer's program, with the cell using its genetic code to process environmental inputs and produce appropriate responses.

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Breakthrough mirror-image nanopores open door to new biomedical applications

For the first time, researchers have successfully fabricated and characterized a fully functional mirror-image nanopore—a molecular gateway built entirely from D-amino acids, the mirror-image forms of the natural building blocks of proteins. The work, led by Prof. Dr. Kozhinjampara R. Mahendran at the Rajiv Gandhi Center for Biotechnology (India) in collaboration with Constructor University and other partners, demonstrates not only a major milestone in nanoscience but also opens promising biomedical applications, including potential cancer therapies.

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DNA repair mechanisms help explain why naked mole-rats live a long life

Naked mole-rats are one of nature's most extraordinary creatures. These burrowing rodents can live for up to 37 years, around ten times longer than relatives of a similar size. But what is the secret to their extreme longevity? How are they able to delay the decay and decline that befalls other rodents? The answer, at least in part, is due to a switch in a common protein that boosts DNA repair, according to new research published in the journal Science.

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