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BCG therapy for bladder cancer does more than act locally—it may reprogram bone marrow to boost anti-tumor immunity. The discovery could broaden the use of immunotherapies and inform new combination treatment strategies.
The Smart Factory in Japan will utilize Cellares' technology platforms to automate cell therapy manufacturing and quality control practices. The methodology reportedly can reduce batch prices by up to 50%.
A looming fetal bovine serum (FBS) supply challenge is threatening cell culture research. As a byproduct of the global beef industry, FBS availability is closely tied to cattle production trends.
Intellia's MAGNITUDE trial is evaluating nexiguran ziclumeran (nex-z), an in vivo CRISPR therapy partnered with Regeneron, designed to treat ATTR-CM by inactivating the TTR gene that drives transthyretin amyloidosis.
Allogeneic CAR-T cell immunotherapy that targets aggressive blood cancers showed promising results alongside manageable side effects in Phase 1/2 clinical trial in patients with T cell acute lymphoblastic leukemia or T cell lymphoblastic lymphoma.
To fight brain disorders, a new suite of genetic tools, known as enhancer AAV vectors, now opens the door to targeted gene therapies that can correct genetic defects in specific cells implicated in disease to minimize unwanted side effects.
We discuss the first patient to be treated with a personalized CRISPR therapy and new CRISPR research. On the business front, 10x settles with Bruker and Vizgen, Illumina sues Element, and Prime downsizes.
Characterizing the components of LNP surfaces paves the way for scientists to engineer more potent and targeted delivery vehicles for RNA-based therapies.
A new technique, EPI-Clone, reads methylation barcodes from individual cells. Here, EPI-Clone was used to reconstruct the history of blood production in both mice and humans, helping trace which stem cells contributed to making blood.
Preclinical research showed SSRI antidepressants boost the ability of T cells to fight cancer and suppress tumor growth in mouse and human tumor models, and identified the serotonin transporter as a promising immune checkpoint target.
This eBook delves into the latest strategies and technologies revolutionizing downstream chromatography, offering insights into process intensification, optimizing chromatographic performance, and addressing HCP challenges in mAb production.
By acquiring Halo Labs, Waters says it will integrate this emerging technology into large molecule development and QA/QC, giving a key value-add to customers while accelerating the company's growth into analytical and bioprocessing testing.
In this GEN webinar, our expert speakers will provide an overview of the current state of NGS-based release testing for biosafety and discuss how a GMP-compliant process can increase biologics manufacturing speeds and improve product safety.
After gaining FDA approval for Miplyffa (arimoclomol) as the first-ever therapy indicated to treat Niemann-Pick disease type C (NPC), Zevra Therapeutics has closed on the $150 million sale of a Rare Pediatric Disease Priority Review Voucher (PRV) that came along with the authorization.
Researchers developed an organoid model of human pluripotent stem cell-derived pancreatic islets with integrated vasculature. The SC-islet organoids with blood vessels contained greater numbers of mature β cells and secreted more insulin than non-vascularized models.
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