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The Palo Alto-based company is developing small molecule drugs that modulate the transcriptome. The latest funding raise will advance IND-enabling studies and clinical preparation of its neurological disease portfolio.
Researchers identified a form of transmissible cancer in a freshwater fish species, in which the cancer cells behave more like parasites than conventional tumors, moving from fish to fish.
Samsung views the deal as expanding its capabilities beyond antibodies and ADCs to include peptide therapeutics, while advancing innovation across high-growth areas such as oncology and other emerging indications.
An analysis of aging human brains revealed widespread immune remodeling, blood-brain barrier deterioration, and genome architecture changes, challenging long-held assumptions about how the brain's resident immune cells are maintained.
Solar energy generates electricity to produce hydrogen, which combines with carbon dioxide to make methanol. Specialized enzymes then convert methanol into specific amino acids, depending on the enzyme combination used.
The results of a mouse study suggest that inflammation during pregnancy can trigger autism-like brain and behavior changes in offspring, and that the effects may be rapidly but temporarily reversible in adulthood with a dose of the immunosuppressive drug rapamycin.
Using single-cell multiomics, spatial transcriptomics, and an AI model called Hicformer, the team generated a multiscale view connecting genome structure, gene regulation, and tissue organization in Alzheimer’s disease.
Atlases like this one can provide the labeled, cell-type-resolved training data that artificial intelligence models need to make accurate predictions—a bottleneck that has historically limited the field.
An oral antiviral candidate prevented airborne and contact transmission of a measles-like virus in ferrets, reduced disease severity and infectious duration, and could complement vaccination strategies to help control future measles outbreaks.
Researchers generated off-the-shelf, mass-producible iPSC-derived allogeneic γδT cells that in a small preclinical study suppressed tumor growth in mouse colorectal cancer xenograft models, highlighting the cells’ potential as a novel immunotherapy for colorectal cancer.
A human study showed that heart attack patients had higher levels of micro- and nanoplastics in their blood, compared with patients diagnosed with chronic ischemic heart disease and normal controls.
The combined solution using Constellation and autoloMATE overcomes fragmentation, limited visibility, and the absence of standardized, interoperable data flows without replacing existing processes, enabling manufacturers to scale to commercially viable levels.
Researchers developed a series of light-activated small molecule drugs that mimic the function of the light-sensing photoreceptor cells that degenerate in diseases such as age-related macular degeneration and retinitis pigmentosa, and which in tests restored sight in blind mice.
Scientists used artificial intelligence to design CRISPR nucleases with properties not found in nature, achieving activity that matches or exceeds natural enzymes despite the proteins' complex, multi-domain structure.
The team’s strategy—called antibody–ADC click—relies on the rapid ligation between trans‑cyclooctene (TCO) and tetrazine moieties.
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