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While Symeres is known for its drug discovery expertise, the expanded capability via spray drying further strengthens its ability to support complex molecules through development and into the clinic.
Findings from a new study suggest that macrophage accumulation and smooth muscle cell loss may contribute to brain aneurysm rupture, identifying potential markers that could help predict rupture risk and prevent stroke.
The study challenges the idea that cellular complexity emerged from a single evolutionary encounter, and point instead to a gradual process of interactions among bacteria and giant viruses lasting millions of years.
Nuvalent’s pipeline is headed by the ROS1 inhibitor zidesamtinib (NVL-520) and the ALK inhibitor eladalkib (NVL-655), which according to the company represent potential best-in-class, next-generation, highly selective treatments for NSCLC. Both are brain penetrant. The FDA has set target decision dates of September 18 for zidesamtinib and November 27 for neladalkib.
Antimicrobial resistance is a serious healthcare issue affecting the world and needs to be taken seriously. Unfortunately, the development of antibiotics is slow and mostly unsuccessful. A new approach is required.
Engineered extracellular vesicles that deliver full-length DMD mRNA to skeletal muscle restored dystrophin production and significantly improved muscle strength and function in Duchenne muscular dystrophy models without notable toxicity.
A GWAS carried out in a genetically diverse population of rats identified genetic markers associated with compulsive cocaine use, and uncovered a potential new therapeutic target in the liver.
Installed in a custom Titan Krios, the laser phase plate boosts small‑protein cryo‑EM by enhancing motion correction, early‑frame recovery, particle visualization, and 3D classification and alignment.
The company's proprietary platform combines an ultrasound-mediated delivery technology with payload engineering capabilities that support the development of DNA and RNA therapeutics, gene editing, and gene silencing approaches.
Researchers at The University of Texas Medical Branch developed a single-dose mRNA vaccine that provided complete protection against the deadly Andes hantavirus infection in animal tests, potentially offering a rapid-response tool for future outbreaks.
This collaboration between Stipple Bio and Lonza combines the former’s epitope discovery capabilities with the latter’s GlycoConnect antibody conjugation technology, HydraSpace polar spacer technology, and a toxSYN linker payload.
New findings suggest that pairing an experimental vaccine adjuvant with injectable polio vaccines can induce a robust immune response in the gastrointestinal tract, potentially reducing virus transmission and supporting global eradication efforts.
Experts urge lawmakers to mandate screening, customer verification, and recordkeeping for synthetic DNA orders and synthesis equipment to strengthen biosecurity as advancing AI lowers barriers to creating biological threats.
Scientists defined a previously undescribed cellular mechanism for fighting pathogens—which they called “antibody-directed xenophagy”—through which cells tag for digestion antibody-coated bacteria and viruses that cross the cell membrane.
D&D‑seq uses a base editor–nanobody fusion to record DNA–protein contacts at single‑cell resolution. The method maps transcription factor and chromatin-remodeling proteins.
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