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Genetic Engineering and Biology News Posts

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ASHG: Signals Based on Clinical Obesity Show Stronger Links to Cardiovascular Health than Those Linked to BMI

Researchers also developed a clinical obesity polygenic score that combined information from numerous genetic variants, a score that was shown to be significantly associated with BMI, body fat percentage, and waist circumference.

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BCG Vaccine-Induced Trained Immunity May Help Protect Against Dementia

The results of a preclinical study suggest that the BCG vaccine, which is widely used to prevent tuberculosis and treat bladder cancer, may also have properties that reduce the risk for dementia by inducing trained immunity.

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ASHG President Susan Slaugenhaupt Calls for Hope, Leadership, and Communication in Science

ASHG President Susan Slaugenhaupt, PhD, opened the society’s Montreal meeting with a heartfelt address emphasizing hope, leadership, and the importance of communication amid the challenges facing science today.

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PerturbAI and OpenAI Launch AI Reasoning Agents for Biomedical Discovery

A year-long collaboration involving scientists at PerturbAI, OpenAI, and their other institutions yielded an AI reasoning framework that turns datasets into testable hypotheses, with thousands of agents analyzing whole-brain genomic data in minutes instead of months.

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Nvidia, UW Institute for Protein Design Unveil Open-Source Protein Design AI Model

RFD4-Proteina is an open model based on Nvidia’s NVIDIA BioNeMo™ artificial intelligence (AI) platform for chemistry and biology that combines programmable protein design with search capabilities. RFD4-Proteina generates targeted protein designs, enabling scientists and agents to search and refine those designs using molecular inputs, constraints, and scoring objectives.

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Proteins Circulating in Blood Linked to Future Risk of Prostate Cancer

The results of a large prospective proteomic study have associated proteins linked with the immune system, cell adhesion, blood vessel formation, and known prostate cancer genes, to future risk of developing prostate cancer, including aggressive disease.

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EQT to Acquire Qiagen for $12.1B, Plans to Take Tools, Diagnostics Provider Private

EQT has €354 billion in assets under management and a three-decade track record of acquiring, developing, and sometimes selling companies that include life sciences tools/tech concerns.

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Cryo-EM and AI-Designed Scaffold Reveal How Andes Hantavirus Binds Cells

Using cryo-EM and an AI-designed scaffold, researchers mapped how Andes hantavirus engages a receptor on human cells. The findings explain how antibodies block attachment and may highlight a potential target for antiviral development.

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Multiomic Study of MSS CRC Identifies Vulnerabilities Pointing to Therapeutic Possibilities

Researchers analyzed mulitomic and clinical data from 2000 colorectal cancer samples and used an AI tool, iPhenMap, to help identify cancer cell vulnerabilities and drug combinations that could be used to treat MSS CRC.

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Wirelessly Powered Electronic Implant, ECHO, Enables Drug-Free Management of ‘Diabesity’

Researchers developed an implantable, wirelessly powered electronic device, ECHO, that uses electrocatalysis to remove excess glucose from the bloodstream on demand, and could offer a drug-free approach to managing obesity and type 2 diabetes (T2D).

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Thirty Million Compartments: Testing Single-Molecule PCR’s Potential

Countable Labs has named Fred Hutchinson its first certified service provider, currently serving researchers across the Seattle region. And the company is continuing to build its list of service providers.

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Illumina Combines Multiomics Informatics Applications in New BioInsight Platform

Illumina is bringing its software, AI, and data offerings together in the new BioInsight platform, designed to help scientists analyze genomic and multiomic datasets. It will be showcased at ASHG in Montreal.

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How Alzheimer’s Risk Gene APOE4 Disrupts Myelination

Study linked the APOE4 gene with suppression of Wnt signaling in the oligodendrocyte cells that provide neurons with their fatty myelin insulation, and also demonstrated a potential approach to preventing disruption of myelination.

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Newly Identified Microexons Offer Clues to Autism Spectrum Disorder’s Genetic Roots

Hundreds of newly identified microexons seem to matter for autism and other neurological conditions, according to a Nature study. A machine learning model of their regulatory code also pinpoints variants predicted to disrupt their splicing in autistic individuals.

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Proteomics Reveals Ovarian Remodeling Decades After Menopause

5,812 protein groups were quantified in postmenopausal ovaries, uncovering molecular shifts associated with inflammation, immunity, and extracellular matrix remodeling.

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