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Genetic Engineering and Biology News Posts

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Unlocking the Potential of Transcription Factors

How siRNA, omics, and AI could enable 100 new FDA approvals by 2045.

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A Noble Pursuit: Biotech Pioneers Remembered

Remembering some of the key players from the origin of the biotechnology industry.

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Unclogging the Downstream Bottlenecks in Bioprocessing

Advances in purification processes plus better management tools help ensure efficient production of pure products.

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Largest Genetic Map of Human Metabolism Created

The largest genetic map of human metabolism has been created using data from ~450,000 individuals through the UK Biobank, revealing how genetic variation affects blood metabolites, disease risk, and potential targets for new therapies.

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What Comes Next? Industry Takeaways from FDA’s Cell and Gene Therapy Listening Session

In this GEN webinar, an outstanding panel of CGT experts will unpack some of the key themes raised during the recent FDA Listening Session and examine their implications for the future of product development and regulatory strategy.

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NIH Funding Cuts’ Impact on Drug Discovery and Development

To quantify the impacts on biomedical research and innovation that NIH funding cuts might have, researchers analyzed small-molecule drug patents to determine how many NIH funded projects were involved in the discovery and development of those drugs.

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Bridge Recombinase Platform Enables Megabase-Scale Human Genome Rearrangements

Bridge recombinase technology developed for use in human cells allows scientists to manipulate large genomic regions by inserting new genes, deleting entire gene clusters, or inverting regulatory sequences.

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Epigenetic Mechanisms Explain Inheritance of Longevity Markers in C. Elegans

Lysosomal changes promote longevity by modifying histones and transmitting these alterations into the germline, enabling C. elegans offspring to inherit lifespan benefits from their parents.

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Microfluidics-Manufactured Lipopolyplexes Offer Size Consistency

A two-step microfluidics system created ternary nano-scale lipopolyplexes, using polymer choice to determine the lipopolyplexes’ structure, which affects vector size and distribution. This overcomes barriers to manufacturing and creates nonviral vectors for efficient DNA delivery.

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Lonza’s Synaffix Collaborates with Qurient Therapeutics on Dual-Payload ADC Development

Dual-payload ADCs are designed to deliver two separate cytotoxic agents with distinct mechanisms of action to target cancer cells, aiming to enhance therapeutic efficacy and mitigate payload resistance.

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Cancer Metabolism and RNA Regulation Linked by Single Protein in Leukemia

The protein, IGF2BP3, is a “master switch” that rewires energy use and RNA regulation in leukemia. Blocking this dual pathway could cut off both the fuel and survival signals cancer cells need to thrive.

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BPI 2025 Debrief and Takeaways

In this episode of GEN's Touching Base, GEN’s editors who attended BPI talk about their experience speaking with other attendees and company representatives on the floor, attending talks during the week, and joining an in-person event sponsored by GEN’s parent company, Sage.

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Concept Life Sciences Expands Integrated Drug Discovery Facilities

The expanded facilities, including custom-fit drug discovery solutions across a range of modalities and therapy areas, are also expected to provide life-sciences job opportunities in the Manchester and Sheffield region.

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Pan-Cancer Immunotherapy Avoids Healthy Tissue by Targeting Glycans

Targeting cancer-associated glycans with binding proteins can trigger tumor cell death without toxicity to surrounding tissue. The glycan-dependent T cell recruiter (GlyTR) compounds were safe and effective in models for a spectrum of cancers, including breast, colon, lung, ovaries, and more.

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Tuned Toxin Expression Helps Candida albicans Evade Detection in the Mouth

Candida albicans uses the toxin candidalysin not just to infect, but to silently colonize oral mucosa. Precise toxin levels are crucial—too little hinders colonization, too much triggers immune response.

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