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Venetoclax, a cancer drug that inhibits BCL-2, reduced the intact SIV reservoir in macaques, offering preclinical support for targeting BCL-2 as part of HIV cure strategies.
A new study from CHOP challenges the assumption that infant C. difficile colonization is harmless, finding that it can reshape the developing gut and immune system with potentially lasting health effects.
Researchers used a novel human 3D micro-bladder model to demonstrate how phage therapy could help to reduce recurrent urinary tract infections (UTIs) by attacking the reservoirs of bacteria hidden deep within the bladder wall, which antibiotics can’t address.
Medicines Discovery Catapult provided its investment and expert support to help two biotech companies accelerate the development of new treatments for a range of autoimmune, inflammatory, and age-related diseases.
The collaboration brings together Synastra’s expertise in genomic engineering, AAV vector design, rare-disease gene therapy, and translational development with NewBiologix’s proprietary cell engineering and rAAV manufacturing technologies.
Study showed nearly all mothers had detectable organophosphate pesticide levels in urine during pregnancy, yet the team found no significant relationship in children between this exposure and traits related to autism.
In this GEN webinar, our expert speaker, Cindy Cheng, PhD, will explore how mechanism-driven payload pairing counters specific resistance pathways by combining orthogonal or complementary mechanisms.
The Phase I dose escalation trial of ACESOT-1051 (NCT06260514) will accelerate its patient enrollment, with Aprea planning to more than triple its number of active clinical sites for the study from three to 10. The expansion is expected to accelerate the pace of clinical data generation by raising monthly enrollment to between six and 10 patients by the fourth quarter.
A preclinical study showed how chemically enhanced suppressor tRNAs combined with a lung-targeted delivery system can restore production of a critical protein in models of cystic fibrosis caused by nonsense mutations.
A landmark molecular map revealed shared pathways connecting diverse autism risk genes. Now, a $46 million investment will help QBI scientists and their collaborators pursue new precision medicines.
By targeting specific neuron types in the Drosophila brain, researchers linked distinct octopamine/tyramine cell types to behaviors including aggression suppression and visual motion tracking.
This eBook introduces the latest trends in quantitative spatial biology and how IMC is accelerating their adoption and success.
Researchers at Charité report promising results from the first CAR T-cell trial for treatment-refractory rheumatoid arthritis, with all six patients improving and three achieving sustained medication-free remission.
By modulating Notch and T cell receptor signaling, scientists have produced functional CD4+ T cells from iPSCs, potentially advancing scalable, off-the-shelf CAR T therapies.
Researchers identified the immune cell population responsible for producing autoantibodies after SARS-CoV-2 infection, and uncovered the molecular program that drives this response, providing insights that might point to new therapeutic targets.
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